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We went on to genotype codons 127 and 129 in the complete patient and control populace . The PRNP codon 129 polymorphism is normally common over the Eastern Highlands Province. The youthful population in kuru-uncovered areas has a higher frequency of the 129V allele than perform adjacent unexposed populations of the Eastern Highlands Province . Areas outside the Eastern Highlands Province, including coastal and inland regions of Papua New Guinea and neighboring islands, have a minimal frequency of the 129V allele, like the frequency in the others of southeast Asia and the Pacific Islands and in marked contrast to the frequency in the Eastern Highlands Province .