ALK33-003 is a Phase 1

ALK33-003 is a Phase 1, randomized, double – blind, placebo-controlled, multi – study designed the the steady-state pharmacokinetics, safety and tolerability of ALKS About 30 Approximately 30 healthy subjects will be randomized successive successive, once-daily dosing of two dose levels of two dose levels of ALKS or placebo .

ALKS 33 Study designALK33-004 one phase 1, randomized, single – blind, placebo-controlled, single-dose study designed to evaluate the ability of ALKS 33 in order to effects of an effects of opioid agonist block, remifentanil, a commercially available analgesic. Approximately 24 healthy, non – dependent, opioid – experienced patients will be randomized to receive a placebo dose as well as one of two dose levels of ALKS 33rd The ability of ALKS 33 to block the effects of remifentanil will be measured by pupillometry assessments and subjective measures opioid effects. The pharmacokinetics and safety of ALKS 33 will also be evaluated.

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