Axel Hauschild.

Other inclusion requirements were age of 18 years or older, a complete life expectancy of 3 months or longer, an Eastern Cooperative Oncology Group performance status of 0 or 1 , and sufficient hematologic, hepatic, and renal function. Individuals were excluded if they had a history of malignancy within days gone by 5 years or metastases to the central nervous program, unless such metastases have been definitively treated a lot more than 3 several weeks previously without progression and no requirement of ongoing glucocorticoid therapy. Concomitant treatment with any other anticancer therapy was not allowed. The protocol was approved by the institutional review board at each participating institution and was conducted relative to the ethical principles of the Declaration of Helsinki and within the nice Clinical Practice guidelines, as defined by the International Conference on Harmonization.Pepper Older Americans Independence Middle and the Boston University Clinical and Translational Science Institute. Testosterone and placebo gels for the analysis were supplied by Auxilium Pharmaceuticals, which had no function in the look or execution of the scholarly research, the interpretation or analysis of the data, or the planning of the manuscript. The trial was designed by the authors, and the trial protocol was approved by the institutional review board at each participating center. The design and maintenance of the data source and the data collection were supervised by the Boston University College of Public Health Data Coordinating Center.