Drug transporters play a vital role in mediating drug disposition throughout the body.

We feel strongly that models of human being origin will ultimately be the tools of choice in future drug advancement programs. This grant is another step in the commitment by the FDA to reach the goal of Translational Medicine.. Absorption Systems awarded FDA SBIR grant for developing its CellPort Technology testing platform Absorption Systems LP today announced that it has been awarded a Phase II Small Business Innovation Study grant from the U.S. This original assay platform enables more particular prediction of potential drug-medication interactions mediated by human drug transport proteins.Siscovick, M.D., M.P.H., Walter C. Willett, M.D., Dr.P.H., and Eric B. Rimm, Sc.D.: Mercury Exposure and Risk of CORONARY DISEASE in Two U.S. Cohorts Controversy has arisen on the risks and benefits of fish intake in adults. Fish intake is associated with the risk of cardiovascular system disease inversely, fatal coronary heart disease especially, and ischemic stroke.1 Fish will be the major source of contact with methylmercury also.2,3 Chronic, low-level methylmercury exposure appears to cause subtle but measurable neurodevelopmental delay in infants, in fact it is recommended that women of childbearing age, nursing or pregnant mothers, and infants and young children eat no more than two servings of fish per week and also limit their intake of selected species of fish that are especially high in methylmercury content.4 In adults, however, the main wellness concern is potential cardiovascular toxicity, as suggested by outcomes of experiments in animals and limited studies in humans.2,5 Prior clinical studies of mercury exposure and cardiovascular diseases have already been relatively small, and the full total results have been inconsistent.1,12-15 We prospectively investigated the relationships between mercury incident and exposure cardiovascular disease in two large U.S.