Maaike de Boer.

Maaike de Boer, M.D., Carolien H .M. Van Deurzen, M.D., Jos A.A.M. Van Dijck, Ph.D., George F. Borm, Ph.D., Paul J. Van Diest, M.D., Ph.D., Eddy M.M. Adang, Ph.D., Johan W.R. Nortier, M.D., Ph.D., Emiel J.T. Rutgers, M.D., Ph.D., Caroline Seynaeve, M.D., Ph.D., Marian B.E. Menke-Pluymers, M.D., Ph.D., Peter Bult, M.D., Ph.D., and Vivianne C.G. Tjan-Heijnen, M.D., Ph.D.: Micrometastases or Isolated Tumor Cells and the Outcome of Breast Cancer The position of the axillary lymph nodes may be the most essential prognostic element in breast cancer. 1 These nodes can be sampled by axillary lymph-node dissection or sentinel-node biopsy with or without subsequent axillary lymph-node dissection .

The Slc25a12-knockout mouse thus seems to represent a style of the human disease. The hypomyelination in our patient was confined to the cerebral hemispheres, with results normal in the cerebellum and brainstem essentially. In the mouse, AGC1 and AGC2 have overlapping expression patterns during embryonic development, and full tissue-specific expression is definitely attained postnatally.2,10 The ontogeny of tissue-specific expression of AGC1 in the human central nervous system is unknown, and residual expression of AGC2 might explain the regional differences observed in our patient. The difference in phenotypes associated with AGC1 insufficiency and AGC2 deficiency is consistent with the different tissue-expression patterns of these two isoforms, leading to metabolic disturbances in the central nervous system and the liver, respectively.