All individuals met the requirements for receiving high-dosage interleukin-2 treatment and experienced no major cardiac, pulmonary, or renal diseases. Details regarding the inclusion criteria are provided in the Supplementary Appendix, offered by NEJM.org. Treatment All individuals received interleukin-2 at a dose of 720,000 IU per kilogram of body weight every 8 hours since an intravenous bolus. The vaccine group also received the HLA*A0201-limited peptide gp100:209-217, amino acid sequence IMDQVPFSV . It had been acquired from the CTEP under investigational-new-drug program BB6123 and was supplied in vials that contains 1 mg of the peptide per milliliter of sterile water. Before administration in the subcutaneous cells of the thigh, the peptide was mixed with Montanide ISA-51 adjuvant provided by the CTEP under investigational-new-drug application BB5924.The results that accreditation stimulates positive changes in safety-related organizational processes and structures are significant, given that few research have examined the effect of Joint Commission accreditation in nursing homes. The lead author of the scholarly study – Laura M. Wagner, Ph.D., R.N., an associate professor at the brand new York University College of Nursing at the Hartford Institute for Geriatric Nursing – notes that the research is certainly both timely and of great importance given that senior managers, like the nursing home administrators and directors of nursing who had been surveyed, can influence the culture of an organization greatly. Related StoriesHigh dosage flu vaccines significantly decrease hospitalization risk during influenza seasonMary Naylor named recipient of GSA's Doris Schwartz Gerontological Nursing Study AwardBystander CPR may prevent brain harm, nursing home entrance following cardiac arrest It’s been suggested that the procedure of sustaining the amount of standards compliance required for accreditation can create a safety-oriented culture within a facility, and our results appear to support this contention, says Wagner.