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Eagerly at work on the engineering of the diagnostic systems for deep vein thrombosis are ten leading European research institutes and high-tech enterprises, the core of the future analytical device, a lab-on – chip, has been built and tested IZM. It is a small, are integrated.fted disposable cartridge which as a tool for biochemical analysis has a drop of blood. It consists of a polycarbonate plate measuring 3 mm x 22 mm x 70 mm, and unites two critical components in one device: the most important component – a foil of 150 micrometers thickness, on which a filigree network with conductor paths and gold sensors for blood analysis is attached, as well as a 120 micrometers deep fluid channel for conducting blood to the analysis elements. Within the sensor chamber to the electrode to the electrode the concentration of the the concentration of the blood coagulation markers analyzed are integrated. If the number is increased, then the risk of a thrombus – ie a blood clot – forms.
ARD1A blocked the expression VEGFA , a key mediator for the the growth of blood vessels in tumors. It is expression of VEGFA regulated induces indirectly through acetylation of transcription factor, VEGFA expression of – hypoxic inducible factor in 1 (HIF-1 acetylation by ARD1A solves reducing HIF-1a , which inhibited VEGFA expression of and blood vessel proliferation in tumor?.