VEGF normally promotes growth of endothelial cells, which in turn helps to build new blood vessels in tumors. To work, are built poorly and do a terrible job with blood and oxygen – and drugs. Cutting VEGF in the tumor in turn increases the activity of cells called pericytes that surround the blood vessels, stabilizing them and makes them more susceptible to chemotherapy, Cheresh said.
Tumors too much VEGF in their haste to form blood vessels on the on the receptor complex. If you take away the VEGF, you lift your foot of the brake, he said, so go to the pericytes to work, maturing blood vessels. The same mechanism is at work during wound healing. ###Reference : Current Pain and Headache Reports, December 2006.. Cheresh the group found that to form receptors for VEGF and other growth-promoting proteins, a complex which eliminates the activity of the PDGF and blood vessel supporting cells.There have been 29 treatment-emergent side effects, frequent injection site out of were have been, from 24 patients of which 10 patients with probable Alzheimer and 14 of which were healthy volunteers have been reported. In two patients with probable Alzheimer’s disease and three healthy volunteers, the AEs were considered will be related florbetaben and included fatigue, ‘feeling hot ‘, increased blood pressure, hematoma and ‘shaken of both hands. ‘All of adverse events the study have been resolved during the study. ‘Alzheimer that the victims and their families, and provides a large and expanding cost burden for society,’said Douglas Stefanelli, Vice President and General Manager, Diagnostic Imaging, Bayer Schering Pharma.